Derek LeRoith Selected Research

Hyperinsulinism (Hyperinsulinemia)

1/2019	Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer.
11/2018	Diabetes, Obesity, and Breast Cancer.
4/2018	Hyperinsulinemia Promotes Esophageal Cancer Development in a Surgically-Induced Duodeno-Esophageal Reflux Murine Model.
10/2016	Metabolic syndrome and pre-diabetes contribute to racial disparities in breast cancer outcomes: hypothesis and proposed pathways.
1/2016	Metabolic Syndrome, Type 2 Diabetes, and Cancer: Epidemiology and Potential Mechanisms.
1/2016	EMT reversal in human cancer cells after IR knockdown in hyperinsulinemic mice.
12/2015	Ovariectomy is associated with metabolic impairments and enhanced mammary tumor growth in MKR mice.
7/2015	Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality.
10/2013	Diabetes, antihyperglycemic medications and cancer risk: smoke or fire?
10/2013	Insulin receptor phosphorylation by endogenous insulin or the insulin analog AspB10 promotes mammary tumor growth independent of the IGF-I receptor.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Derek LeRoith Research Topics

Disease

55	Neoplasms (Cancer) 01/2022 - 02/2002
42	Type 2 Diabetes Mellitus (MODY) 10/2021 - 10/2002
36	Insulin Resistance 01/2022 - 10/2002
29	Breast Neoplasms (Breast Cancer) 12/2021 - 08/2003
21	Hyperinsulinism (Hyperinsulinemia) 01/2019 - 11/2004
20	Obesity 10/2021 - 12/2006
14	Hyperglycemia 11/2018 - 10/2002
7	Dyslipidemias (Dyslipidemia) 11/2018 - 11/2004
7	Neoplasm Metastasis (Metastasis) 01/2016 - 02/2002
5	Inflammation (Inflammations) 01/2017 - 03/2005
4	Lung Neoplasms (Lung Cancer) 11/2021 - 02/2002
4	Triple Negative Breast Neoplasms 01/2021 - 10/2014
4	Carcinogenesis 04/2018 - 09/2010
4	Body Weight (Weight, Body) 10/2017 - 02/2011
3	Hypercholesterolemia 01/2021 - 12/2015
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2017 - 11/2007
3	Hypoglycemia (Reactive Hypoglycemia) 10/2005 - 06/2003
2	Sepsis (Septicemia) 01/2022 - 01/2017
2	Cognitive Dysfunction 01/2020 - 10/2015
2	Autoimmune Diseases (Autoimmune Disease) 01/2019 - 07/2015
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 06/2016 - 07/2015
2	Carcinoma (Carcinomatosis) 09/2015 - 05/2013
2	Colorectal Neoplasms (Colorectal Cancer) 02/2015 - 04/2008
2	Fatty Liver 05/2013 - 11/2004
2	Hyperplasia 06/2011 - 06/2003
2	Hypertrophy 10/2010 - 11/2008
2	Diabetes Mellitus 09/2010 - 02/2004
2	Prostatic Neoplasms (Prostate Cancer) 03/2010 - 05/2008
2	Osteosarcoma (Osteogenic Sarcoma) 05/2009 - 10/2003
2	Adenocarcinoma 05/2008 - 02/2002
2	Colonic Neoplasms (Colon Cancer) 04/2008 - 02/2002
2	Starvation 12/2004 - 06/2004
1	Septic Shock (Toxic Shock Syndrome) 01/2022
1	HIV Infections (HIV Infection) 01/2022
1	Multiple Organ Failure (MODS) 01/2022
1	Endometrial Neoplasms (Endometrial Cancer) 12/2020

Drug/Important Bio-Agent (IBA)

43	Insulin (Novolin)FDA Link 10/2021 - 10/2002
29	Insulin-Like Growth Factor I (IGF-1)IBA 07/2015 - 02/2002
28	Glucose (Dextrose)FDA LinkGeneric 10/2021 - 06/2003
15	Insulin ReceptorIBA 12/2020 - 09/2005
13	IGF Type 1 Receptor (IGF 1 Receptor)IBA 10/2013 - 06/2003
12	Insulin-Like PeptidesIBA 11/2018 - 06/2003
9	LipidsIBA 01/2022 - 07/2003
8	Metformin (Glucophage)FDA LinkGeneric 01/2022 - 04/2010
8	CytokinesIBA 01/2022 - 11/2007
8	Hormones (Hormone)IBA 01/2022 - 12/2006
7	AdipokinesIBA 01/2020 - 02/2011
6	Blood Glucose (Blood Sugar)IBA 10/2021 - 01/2004
6	Triglycerides (Triacylglycerol)IBA 10/2017 - 10/2003
5	Proteins (Proteins, Gene)FDA Link 12/2021 - 10/2003
5	Small Interfering RNA (siRNA)IBA 11/2019 - 06/2004
5	Growth Hormone (Somatotropin)IBA 10/2017 - 10/2003
5	Hypoglycemic Agents (Hypoglycemics)IBA 12/2016 - 09/2005
5	Messenger RNA (mRNA)IBA 09/2015 - 10/2003
4	CholesterolIBA 01/2021 - 11/2004
4	Estrogens (Estrogen)FDA Link 12/2020 - 12/2006
4	Nonesterified Fatty Acids (NEFA)IBA 06/2019 - 10/2002
4	Tumor Viral Antigens (Large T Antigen)IBA 01/2016 - 08/2003
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2016 - 02/2002
4	Transcription Factors (Transcription Factor)IBA 01/2016 - 10/2003
4	Insulin-Like Growth Factor II (Somatomedin A)IBA 10/2014 - 06/2003
3	Somatomedin Receptors (Somatomedin Receptor)IBA 12/2020 - 12/2013
3	ChemokinesIBA 01/2020 - 12/2013
3	Pharmaceutical PreparationsIBA 09/2014 - 09/2010
3	LeptinIBA 12/2013 - 09/2005
3	CarbohydratesIBA 01/2012 - 11/2004
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2010 - 02/2002
3	Insulin-Like Growth Factor Binding Protein 3IBA 10/2003 - 09/2002
2	Peptide Hormones (Polypeptide Hormones)IBA 01/2022 - 10/2012
2	Biological ProductsIBA 10/2021 - 10/2013
2	LDL CholesterolIBA 01/2021 - 01/2018
2	Estradiol (Delestrogen)FDA LinkGeneric 12/2020 - 12/2015
2	Estrogen ReceptorsIBA 12/2020 - 03/2012
2	salicylhydroxamic acid (SHAM)IBA 01/2020 - 12/2015
2	Interleukin-6 (Interleukin 6)IBA 11/2018 - 01/2016
2	LigandsIBA 11/2018 - 02/2007
2	Lysine (L-Lysine)FDA Link 04/2018 - 08/2006
2	Arginine (L-Arginine)FDA Link 04/2018 - 08/2006
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2018 - 01/2007
2	Insulin Glargine (Lantus)FDA Link 01/2017 - 01/2016
2	Sirolimus (Rapamycin)FDA Link 12/2016 - 12/2010
2	Advanced Glycation End ProductsIBA 04/2016 - 03/2005
2	VimentinIBA 01/2016 - 06/2013
2	disodium (R,R)- 5- (2- ((2- (3- chlorophenyl)- 2- hydroxyethyl)- amino)propyl)- 1,3- benzodioxole- 2,3- dicarboxylateIBA 01/2016 - 03/2010
2	AdiponectinIBA 12/2013 - 08/2006
2	SteroidsIBA 10/2012 - 12/2006
2	Streptozocin (Streptozotocin)FDA Link 12/2004 - 06/2003
2	PPAR alphaIBA 04/2004 - 07/2003
1	Oxytocin (Pitocin)FDA LinkGeneric 01/2022
1	Vasopressins (Vasopressin)IBA 01/2022
1	AntibodiesIBA 12/2021
1	Ion Channels (Ion Channel)IBA 12/2021
1	insulin receptor-related receptor (IRR)IBA 11/2021
1	Glucose Transporter Type 4IBA 10/2021
1	LDL Receptors (LDL Receptor)IBA 01/2021
1	ErbB Receptors (EGF Receptor)IBA 01/2021

Therapy/Procedure

23	Therapeutics 01/2022 - 03/2004
4	Glycemic Control 10/2015 - 01/2007
3	Drug Therapy (Chemotherapy) 12/2016 - 03/2004
1	Art Therapy 01/2022